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Comparison of Benfotiamine
to Thiamine
Pharmacokinetics of Thiamine Derivatives Especially of Benfotiamine
Loew D.
Wuppertal, Germany.
Int J Clin Pharmacol Ther. 1996 Feb;34(2):47-50.
Abstract
Pharmacokinetic data of
orally administered lipid-soluble thiamine analogues like benfotiamine
are reviewed and assessed. It is quite clear that benfotiamine is absorbed
much better than water-soluble thiamine salts: maximum plasma levels
of thiamine are about 5 times higher after benfotiamine, the bioavailability
is at maximum about 3.6 times as high as that of thiamine hydrochloride
and better than other lipophilic thiamine derivates. The physiological
activity (alphaETK) increased only after benfotiamine was given. Due
to its excellent pharmacokinetic profile benfotiamine should be preferred
in treatment of relevant indications.
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