RESEARCHERS FIND PROMISING DRUG FOR PREVENTING SERIOUS
COMPLICATIONS OF DIABETES
Excerpted
news release from - Albert Einstein School of Medicine
- of Yeshiva Hospital.
February 16, 2003 -- (BRONX, NY)
"Opening
up the possibility of a new approach to the treatment of
diabetes, researchers have shown in animal studies that
a drug long available in Europe can simultaneously block
three of the major biochemical pathways responsible for
the blood-vessel damage that causes serious diabetic complications."
"Dr.
Michael Brownlee of the Albert Einstein College of
Medicine of Yeshiva University was the
senior researcher for the international consortium
that carried out the study, which appears in the current
issue of Nature Medicine."
"Research
over the past 30 years has identified four biochemical
pathways by which diabetes injures blood vessels - damage
that makes diabetes the leading cause of blindness, kidney
failure, heart attacks and nontraumatic amputation of legs
in the U.S. In this study, from the Einstein Diabetes Research
Center, the drug benfotiamine
completely blocked three of those pathways when
tested in diabetic rats, animals often used as models for
studying the disease. Benfotiamine is a synthetic derivative
of thiamine (vitamin B1) and has been available for more
than a decade in Germany. It is prescribed there for treating
diabetic neuropathy, sciatica and other painful nerve conditions."
"In people with diabetes, all cells are
bathed in blood that contains elevated levels of glucose.
Most cells still manage to keep their internal glucose at
normal levels. But certain cells - particularly endothelial
cells that line arteries and the capillaries of the retina
and kidney - are unable to regulate glucose and instead develop
high internal levels of the sugar, which they can't completely
metabolize. As a result, glucose-derived "intermediate" metabolic
products accumulate inside these cells, where they activate
pathways of cellular damage that can eventually lead to blindness
and other complications."
"As
reported in the Nature Medicine paper, benfotiamine successfully
blocked all three major destructive biochemical pathways
in experiments with arterial endothelial cells. Next, the
researchers treated diabetic rats with benfotiamine and
then examined their retinal tissue. (For comparison, they
also examined the retinas of control diabetic rats and
normal rats.)"
"Chemical analysis showed that
all three biochemical pathways had been "normalized" in
the benfotiamine-treated diabetic rats so that their retinas
were biochemically identical to the retinas of normal rats. The
drug also prevented diabetic retinopathy in the animals,
since microscopic examination revealed that the retinas of
benfotiamine-treated diabetic rats were free of vascular
damage."
"In
addition to Dr. Brownlee and his Einstein colleagues, authors
of the Nature Medicine paper included scientists from Germany,
Italy, China and Japan. The research was supported by grants
from the National Institute of Diabetes and Digestive and
Kidney Diseases, the American Diabetes Association and
the Juvenile Diabetes Research Foundation."
# # #
A Health Care Professional's Opinion On Benfotiamine
Dr. Paul Chous
is the recent author of a critically acclaimed book for patients
and health care providers on diabetes and the eye, Diabetic
Eye Disease: Lessons From A Diabetic Eye Doctor – How
To Avoid Blindness and Get Great Eye Care (Fairwood
Press).
Below are excerpts from Dr. Chous' communications and his recent
book:
"I
suspect strongly that benfotiamine will mitigate (or, hopefully,
prevent) diabetic retinopathy."
"The
case for symptomatic relief of neuropathy symptoms is, of
course, more tangible."
"In
a study that may represent a major breakthrough in the prevention
and treatment of diabetic retinopathy and other microvascular
complications of diabetes, a multinational team of researchers
has announced that a lipid soluble form of Vitamin B1 (thiamine)
prevented the development of diabetic retinopathy in rats
over a 36 week period. The synthetic thiamine derivative,
called benfotiamine, has been used safely for more than a
decade in Europe, where it is prescribed to treat painful
neuropathies."
For over
30 years, scientists have known of four biochemical pathways
responsible for the blood vessel damage that causes many
diabetes complications - damage that makes diabetes a leading
cause of eye disease, kidney disease, nerve disease and heart
disease. This study, appearing in the March 2003 issue of
Nature Medicine, shows that benfotiamine completely blocked
three of these four chemical pathways, and prevented the
development of retinopathy in diabetic rats, whereas control
animals all developed some degree of retinopathy."
"Moreover,
this compound has long been used in Germany without reported
side effects."
"Interesting
to note that benfotiamine is naturally found in cooked garlic,
though at low levels."
"Add to this the fact that there is a substantial body
of evidence that demonstrates many patients with diabetes have
thiamine deficiencies, and as benfotiamine represents a much
more bioavailable form of thiamine, it seems to me that the
use of benfotiamine is scientifically "rational."
"I
suspect it may be widely recommended in years to come."
#
# #
Vitamin B12: Under Appreciated
Excerted from and article by
Richard A. Kunin, M.D.
“I
have recently treated over half a dozen patients whose lives
have been ruined by vitamin B12 deficiency--a preventable
disorder. In every case there was medical error and/or patient
ignorance and skepticism leading to permanent harm. It is
easy to miss the diagnosis of vitamin B12 deficiency. In
the first place, it is a vitamin and our medical education
is not only weak on vitamin diagnosis, it often reviles those
doctors who treat with vitamins.”
”The practical effects of B12 activity are straight-forward.”
”Activation of the vitamin, folic acid, redoubles anti-cancer effect and
together they support synthesis of myelin, the insulating covering of nerves.”
”Production of myelin, the insulation of nerves. Repair of nerves prevents
damage to the spinal cord and brain, so-called subacute combined degeneration.
This involves pain (early) and loss of muscle perception and vibration sense
(late) in the hands and feet. It also causes mental impairment, typically with
paranoia and depression, is similar to Alzheimer’s. In fact, about 30 percent
of patients with Alzheimer’s actually have B12 deficiency.”
Vitamin B12 does not fit the mold of the deficiency diseases theory, or the
one-disease-one-drug model of medicine that is taught in medical schools. The
most important medical fact about vitamin B12 is that deficiency does not show
up only as anemia. In fact, in many cases there is no anemia, only neurological
symptoms, such as numbness in the extremities, inability to walk and stay in
balance, especially at night or in the dark, and serious personality changes,
such as depression and paranoia. Unlike the anemia, which always responds to
B12 replacement, if the nerve and brain symptoms are not treated promptly the
damage is likely to be permanent.
”One reason is that most doctors expect to find B12 problems in patients
past age 60; and therefore may fail to consider it in younger folks. One of my
patients was only 28 when B12 deficiency reached a critical state. Patricia had
been able to cover-up her mental fuzziness and depression for years but the pain
in her extremities finally drove her to seek medical help. Somehow the diagnosis
was missed at two medical centers. Only after she had a severe progression of
spinal cord damage following anesthesia for laparoscopic surgery did the diagnosis
become obvious.”
#
# #
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